This Study is Forcing Scientists to Rethink the Human Genome. The more data, the better, right? When it comes to genetics, it turns out that might not be the case. You have not yet voted on this site! If you have already visited the site, please help us classify the good from the bad by voting on this site.![]() As both genetic sequencing has gotten cheaper and computerized data analysis has gotten better, more and more researchers have turned to what are known as genome- wide association studies in hopes of sussing out which individual genes are associated with particular disorders. The logic here is simple: If you have a whole lot of people with a disease, you should be able to tell what genetic traits those people have in common that might be responsible. This thinking has resulted in an entire catalogue of hundreds of research studies that has shed light on the genetic origins of diseases such as type 2 diabetes, Parkinson’s disease, Crohn’s disease, and prostate cancer, while helping fuel the rise of personalized medicine. Now, though, a new analysis calls the entire approach into question. Writing in the journal Cell, a group of Stanford University geneticists write that such large studies are likely to produce genetic variants with little bearing on the disease in question—essentially false positives that confuse the results. Instead of a system in which you can plug and play different variables to affect different results, it’s a complex, inter- related network.
They call this the “omnigenic model.”Their work has broad, sweeping implications for the entire field of genetics. First off, that all those big, expensive genome- wide association studies may wind up being little more than a waste of time because they turn up genetic variants that, while perhaps interconnected to the disease, may not actually point to a viable target for things like drug therapy. Indeed, genes that often seem related to diseases have stumped researchers in terms of the role they actually play in the condition. In the paper, for example, the Stanford researchers re- analysed a 2. The more data, the better, right? When it comes to genetics, it turns out that might not be the case. As both genetic sequencing has gotten cheaper and computerized. Aging Transformation Scenes manga: A-B C-F G-K L-N O-S T-Z Online 2 Players Games. We have indexed & categorized games from all over the web. Over 100,000 games to choose from! ![]() DNA variants linked to height—but only 1. In the paper, the Stanford researchers suggest that the impact of each variant has a teeny impact on height. Far from solving a problem though, this new research merely opens up an entirely new line of questioning—and shows us once again, that we may not know nearly as much as we thought we did. Kotaku. Track: All Around The World. Xbox One vs Xbox 3. Is it time to upgrade? Xbox One vs Xbox 3. Is it worth upgrading to the new generation? The Xbox One has been around a for three years now and it's well worth considering the upgrade from the Xbox 3. Microsoft has been steadily adding new features to its latest console and it now runs Windows 1. Where, at one time, the Xbox 3. Xbox One when it came to multimedia capabilities the newer console is now the stronger. What's even more exciting is that Microsoft has announced a Xbox One S console at E3 2. It fixes some of the issues with the original Xbox One, namely it hugeness, and adds a 4. K Blu- ray player to the mix. That's pretty impressive considering it will only cost . Should you wait for it? Well that is quite a long time away. We’ll guide you through some of the key things to consider in this piece, before you decide to splash out on a shiny new Xbox. Related: Xbox One S vs Xbox One Related: Xbox Scorpio: Everything you need to know. SEE ALSO: Best Xbox One Deals. Xbox One vs Xbox 3. Design. The Xbox One is a huge, hulking beast with a huge hulking power supply dragging it down. By comparison the Xbox 3. The Xbox One measures an XXL 3. The Xbox 3. 60 is 2. Xbox One. Even the first iteration of the Xbox 3. One of the reasons Microsoft has made the Xbox One so chunky is to give it room to breathe. The smaller Xbox 3. Red Ring of Death problems that cost Microsoft over a billion dollars. There’s no wonder why Microsoft has played it safe with the Xbox One. The Xbox One has been designed to be switched on for its whole anticipated 1. The chunky design all set to change with the svelte Xbox One S. The new Xbox is 4. If you can, wait for it to be released in August before buying an Xbox One. If you’re into voice commands or motion gaming features, you’ll also want to consider the Xbox One Kinect. Originally, it came pre- packaged with the Xbox One console itself, but now you can buy the console cheaper without it. The Xbox One Kinect is smaller than the original Kinect, measuring up at 6. Of course, the Xbox One Kinect is far more advanced than the original, with better body recognition, wider field of vision for play in smaller spaces and enhanced voice commands. We would say that the Xbox One UI is far easier to navigate with Kinect, as often it can be tricky to find certain options or settings with the Wireless Controller alone. The Kinect has dropped down Microsoft's priority list for the Xbox, and rightly so with the advent of virtual reality headsets like the Oculus Rift and HTC Vive. These provide motion controls but add incredible immersion to the experience. Xbox One vs Xbox 3. Noise. Although you might not think noise is an issue when choosing between the Xbox One and Xbox 3. Xbox 3. 60 consoles. The Xbox One is nearly silent when it’s running, partly down to its size of course, because the more space the fans have, the less hard they need to work. You might not notice a huge difference between the latest couple of Xbox 3. Buy Now: Xbox 3. 60 at Amazon. Xbox One vs Xbox 3. CPU and RAMThe Xbox 3. Power. PC- based CPU - it's a triple- core 3. GHz processor. The Xbox One has an eight- core processor based on the AMD Jaguar chip series. Does that mean the Xbox One is two and a half times as powerful as the Xbox 3. No, it's more powerful than that as the efficiency of the CPU is much better, not just the clock speed and number of cores. The increase in RAM is even more marked. The Xbox 3. 60 has 5. MB of RAM, the Xbox One has a whopping 8. GB of RAM. Let's put some performance numbers to it. The Xbox 3. 60 has 0. TFLOPS ( a standard measure of computing performance) whereas the Xbox One has 1. TFLOPS. That's a very big difference indeed. See also: Best Xbox One Games 2. Xbox One vs Xbox 3. Controllers. There isn’t a revolutionary change between the Xbox 3. Xbox One controllers, but Microsoft made some iterative changes that makes the Xbox One Wireless Controller have the edge. The biggest change is what Microsoft is calling the Impulse Triggers. The Xbox One Controller triggers now pack rumble motors. That makes the Xbox One the ultimate console for racing games, as you’ll feel anything from the subtle gear changes to the hard brakes with the left trigger right in your fingertips. It’s a great addition for shooters too, but when you’ve experienced racing games like Forza Horizon 2 with the Xbox One controller, it will feel fantastic. The shoulder buttons have also been enlarged slightly, so there’s not that bizarre gap between R1/R2 and L1/L2 as there was on the Xbox 3. Microsoft has also revamped the D- Pad, making it more clicky, more responsive and altogether better for your old school arcade games. Sadly, the Xbox One Wireless Controller still runs on AA batteries as standard, with the rechargeable pack available as an optional extra. If you want to splash the cash then there's also the refined and customisable Xbox One Elite Controller to consider. Buy Now: Xbox One at Amazon. See also: Best Games 2. Xbox One vs Xbox 3. Games Library. Because the Xbox 3. Plus, Microsoft believes its ageing console will be supported by developers for at least another two years yet, so it’s still worth investing in on a games front. However, as the months roll on you can see the Xbox One’s game resolution and game library getting to be far stronger than its predecessors. You can’t deny that cross- platform games look far better in the 9. Xbox One. It’s getting to the point that developers like Ubisoft are creating two different games to take advantage of the power of the Xbox One and PS4. At launch, the Xbox One didn’t have the strongest of exclusive game line- ups. It had the likes of: Assassin’s Creed 4: Black Flag, Crimson Dragon, Call of Duty: Ghosts, , Capcom's Dead Rising 3, Microsoft Studios' Forza Motorsport 5, Killer instinct and Ryse: Son of Rome. The majority of those were also available on Xbox 3. But in the years since release, we’ve had some strong Xbox One titles such as Forza Horizon 2, the colourful Sunset Overdrive and Halo: The Master Chief Collection. Plus, you’ve got titles like Assassin’s Creed Unity that is only available on new- gen consoles. Backwards compatibility is also now on the cards. More than 2. 00 Xbox 3. Xbox One so you can play a lot of your old favourites on the newer console. Read more: Xbox One backwards compatibility. Xbox One vs Xbox 3. Multimedia features. From launch and even before that, the Xbox One has been touted as the all- in- one entertainment console, and over the past few years, Microsoft has been working hard to fulfil that promise. Originally, the Xbox 3. Xbox One has not only caught up on all fronts, it's also surpassed the ageing console. The Xbox One app line- up currently looks like this: Netflix, Amazon Prime Instant Video, Blink. Box Movies, Wuaki. D, Crackle, Demand 5, Eurosport, Machinima, Muzu TV, Now TV, TED, Twitch, and You. Tube. With the Xbox One now running Windows 1. Windows Store. Impressive stuff. Plus, the Xbox One has some other great features including the Xbox Media Player app (currently in preview) for watching content from a USB or external hard drive and Plex. That means it’s definitely stronger the the Xbox 3. USB 3. 0 external hard drive of 2. GB or above for additional storage on your Xbox One. It doesn't end there. The Xbox One can draw in cable TV feeds from services like Virgin Media or Sky Q and integrate your TV content within the Xbox One UI. There’s even a rather special EPG called the One. Guide that will let you pause/rewind live TV up to 3. Twitter. Even if you don’t have a cable TV subscription, you can fork out an additional . You can pick up the low- end 4. GB Xbox 3. 60 for around . Now, you can pick up the Xbox One, Kinect- free with a game for . It's an old console that's showing it's age, while the Xbox One is going from strength to strength. The Xbox One is the far better option but now may not be the best time to upgrade from Xbox 3. While the Xbox One is the ultimate entertainment console, the Xbox One S is a lot more compact, comes with a UHD Blu- ray player and will cost just a little more at . Keep saving until August and get yourself the newest version. Next, read our. Xbox One S vs Xbox One comparison. Share your thoughts on the Xbox One vs Xbox 3.
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